Cyclophilin D: An Integrator of Mitochondrial Function

Mitochondrial import of cyclophilin-D.

Mammalian mitochondria contain an inner membrane pore which opens following an increase in matrix calcium. Pore opening has been implicated in tissue damage following ischaemic injury. The pore is reversibly blocked by cyclosporin A [l] suggesting a role for cyclophilin in pore control. A mitochondria1 isoform of cyclophilin (CyP-D) [2,3,4,5] has now been identified. Analysis of the N-terminus ...

Cyclophilin D modulates mitochondrial acetylome.

RATIONALE Mice lacking cyclophilin D (CypD(-/-)), a mitochondrial chaperone protein, have altered cardiac metabolism. As acetylation has been shown to regulate metabolism, we tested whether changes in protein acetylation might play a role in these metabolic changes in CypD(-/-) hearts. OBJECTIVE Our aim was to test the hypothesis that loss of CypD alters the cardiac mitochondrial acetylome. ...

Cyclophilin D Modulates the Mitochondrial Acetylome

Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning

AIMS It has been suggested that mitochondrial reactive oxygen species (ROS), Akt and Erk1/2 and more recently the mitochondrial permeability transition pore (mPTP) may act as mediators of ischaemic preconditioning (IPC), although the actual interplay between these mediators is unclear. The aim of the present study is to determine whether the cyclophilin-D (CYPD) component of the mPTP is require...

Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy

A common process associated with oxidative stress and severe mitochondrial impairment is the opening of the mitochondrial permeability transition pore, as described in many neurodegenerative diseases. Thus, inhibition of mitochondrial permeability transition pore opening represents a potential target for inhibiting mitochondrial-driven cell death. Among the mitochondrial permeability transition...